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Bringing Organoids to Life: Vascularization

Advanced Solutions Life Sciences is excited to reveal that its manuscript, "Vascularizing Tissue Organoids," has been published in a special edition of Regenerative Medicine in Bioengineering. The manuscript highlights ASLS’ cutting-edge Angiomics® technology and its various uses to the scientific community.


Tissue organoids, also known as "mini organs," possess vast potential as tools for various applications, such as disease modeling, drug screening, and tissue engineering. To effectively imitate the native tissue environment, it is essential to integrate a microvasculature with the parenchyma and stroma. This is where Angiomics® technology comes into play, as it enables the creation of functional microvasculature within tissue organoids, providing a means to physiologically perfuse the organoids and contribute to the cellular dynamics of the tissue model through the cells of the perivascular niche.


In the manuscript, the state of the art in this field is reviewed, and various strategies for vascularizing tissue organoids are discussed. The significance of perfusion in tissue organoids and how it contributes to the cellular dynamics of the tissue model is highlighted. Additionally, the importance of using human cells to create tissue organoids is discussed, as it provides a significant advantage over in vivo animal models, which are often not representative of cellular and disease behavior in humans.


The advantages of using organoids over other in vitro systems and animal models are also discussed, such as their small size, which limits regions of necrosis that are often present in thicker tissue models, and the potential to be free from synthetic materials, containing only cells and their secreted matrix. Angiomics® technology allows for the creation of organoids that better approximate the in vivo tissue space than 2D cell cultures and mimic native tissue behavior and function with a high level of relevance.


The company takes pride in being at the forefront of this exciting and rapidly advancing field and having its Angiomics® technology recognized by the scientific community. It looks forward to continuing its research and development in this field and creating new and innovative solutions for various applications in regenerative medicine and bioengineering.


The authors of the manuscript are Hannah A. Strobel, Sarah M. Moss, and James B. Hoying, with James B. Hoying as the corresponding author. They are available to answer any questions regarding their technology and research at jhoying@advancedsolutions.com.


View published manuscript:

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