Hyperelastic Bone™ 3D-paint can be 3D-printed at room temperature into multi-layered, three dimensional objects. The resulting extruded material rapidly solidifies, allowing for complex, user-designed forms to be created.
HYPERELASTIC BONETM (HYDROXYAPATITE) 3D-PAINT (3DHB-R1A)
This research grade (not for human use) Hyperelastic Bone™ 3D-paint can be 3D-printed at room temperature using a direct extrusion (pneumatic or mechanical) 3D-printer into multi-layered, three- dimensional objects. The 3D-paint should only be used in a well-ventilated environment. The resulting extruded material rapidly solidifies, allowing for complex, user-designed forms to be created. The resulting solid material, despite being mostly Hyperelastic Bone™, is highlight absorbent, flexible, and may even have elastic properties depending on the printed architecture. The solids loading of the as- dried material is 90 wt.% synthetically derived hydroxyapatite, 10 wt.% polylactide-co-glycolide (PLG). Hyperelastic Bone™ 3D-paint can be utilized to create three-dimensional, or co-3D-printed with other 3D-paints to create multi-material structures. Hyperelastic Bone 3D-paint may also be mixed with other 3D-paints to compound 3D-paints prior to utilization. Due to the mechanical flexibility of the material after drying, complex 2D and 3D forms can be created. 3D-Printed Hyperelastic Bone™ can be rolled, cut, folded, and punched as desired. It may even be sutured to itself or to soft tissues. The Hyperelastic Bone™ 3D-paint may also be utilized in non-3D-printing applications such as coating (dip-coating or direct painting), thread fabrication, or casting into molds.
This research grade Hyperelastic Bone™ 3D-paint is comprised of a mixture of micron-scale Hyperelastic Bone particles suspended in a mixture of organic solvents containing a dissolved, high molecular weight elastomeric, biocompatible polyester (polylactic-co-glycolic acid; PLGA). After 3D-printing or other application, Hyperelastic Bone™ should be washed in 70% ethanol or 70% isopropyl alcohol followed by water, to remove residual solvents, prior to use. It can be utilized in this form, as a flexible, bioactive, biocompatible ceramic composite, or it can be sintered (1500 °C recommended) in a non-oxidative atmosphere to yield dense hydroxyapatite parts. As sintered, Hyperelastic Bone is highly chemically and thermally stable, and can be used for a wide variety of high temperature applications. Hyperelastic Bone™ also has numerous hard biological tissue (teeth and bone) applications, and can serve in it as as- printed, washed form as flexible ceramic composite cell scaffold, or in its sintered form, as a rigid ceramic scaffold/implant. In its 3D-printed, flexible form, Hyperelastic Bone™ has been shown to be highly osteoconductive, and osteogenic, capable of differentiating adult human stem cells into osteoblast-like cells.