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Publications

The Advanced Solutions team and collaborators routinely publish the groundbreaking research. When you choose an Advanced Solutions product, you get a partner in research there to support you throughout your discovery.

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Cell-based therapies for vascular regeneration: Past, present and future

Yasaman Aghazadeh, Safwat T. Khan, Blessing Nkennor, Sara S. Nunes

Sep 1, 2021

Pharmacology & Therapeutics

Microvessels support engraftment and functionality of human islets and hESC-derived pancreatic progenitors in diabetes models

Yasaman Aghazadeh, Frankie Poon, Farida Sarangi, Frances T.M. Wong, Safwat T. Khan, Xuetao Sun, Rupal Hatkar, Brian J. Cox, Sara S. Nunes, M. Cristina Nostro

Aug 31, 2021

Cell Stem Cell

Quantifying vascular density in tissue engineered constructs using machine learning

Hannah A. Strobel, Alex Schultz, Sarah M. Moss, Rob Eli, James B. Hoying

Apr 27, 2021

Frontiers in Physiology - Computational Physiology and Medicine

Vascularized adipocyte organoid model using isolated human microvessel fragments

Hannah A. Strobel, Thomas Gerton, James B. Hoying

Apr 7, 2021

Biofabrication, Volume 13, Number 3

3D Bioprinted Bacteriostatic Hyperelastic Bone Scaffold for Damage-Specific Bone Regneration

Mohammadreza Shokouhimehr, Andrea S. Theus, Archana Kamalakar, Liqun Ning, Cong Cao, Martin L. Tomov, Jarred M. Kaiser, Steven Goudy, Nick J. Willett, Ho Won Jang, Christopher N. LaRock, Philip Hanna, Aron Lechtig, Mohamed Yousef, Janaiana Da Silva Martins, Ara Nazarian, Mitchel B. Harris, Morteza Mahmoudi, Vahid Serpooshan

Mar 30, 2021

Polymers, Volume 13, Edition 7

Maturation of in situ bioprinting

James B. Hoying

Jan 26, 2021

Journal of 3D Printing in Medicine, Volume 4, Number 4

Improvement of islet transplantation by the fusion of islet cells with functional blood vessels

Lisa Nalbach, Leticia P. Roma, Beate M. Schmitt, Vivien Becker, Christina Korbel, Selina Wrublewsky, Mandy Pack, Thomas Spater, Wolfgang Metzger, Maximilian M. Menger, Florian S. Frueh, Claudia, Gotz, Haopeng, Lin, Joseline E. Manning Fox, Patrick E. MacDonald, Michael D. Menger, Matthias W. Laschke, Emmanuel, Ampofo

Jan 11, 2021

EMBO Molecular Medicine, Volume 13

An Integrated Design of Polypseudorotaxane-Based Sea Cucumber Mimic

Longyu Li, Qianming Lin, Miao Tang, Esther H.R. Tsai, Chenfeng Ke

Jan 1, 2021

Angwandte Chemie

Microvascular Fragments: More Than Just Natural Vascularization Units

Matthias W. Laschke, Thomas Spater, Michael D. Menger

Jan 1, 2021

Trends in Biotechnology, Volume 39, Issue 1

3D Bioprinting of Neural Tissues

Melissa Cadena, Liquin Ning, Alexia King, Boeun Hwang, Linqi Jin, Vahid Serpooshan, Steven A. Sloan

Nov 16, 2020

Advanced Healthcare Materials, Volume 10, Issue 15

Mechanical Considerations of Bioprinted Tissues

Hannah A. Strobel, Sarah M. Moss, James B. Hoying

Oct 28, 2020

Frontiers in Mechanical Engineering - Digital Manufacturing

Transplanted microvessels improve pluripotent stem cell-derived cardiomyocyte engraftment and cardiac function after infarction in rats

Xuetao Sun, Jun Wu, Beiping Qiang, Rocco Romagnuolo, Mark Gagliardi, Gordon Keller, Michael A. Laflamme, Ren-Ke Li, Sara S. Nunes

Sep 23, 2020

Science Translational Medicine, Volume 12, Issue 562

Scaffold Architecture and Matrix Strain Modulate Mesenchymal Cell and Microvascular Growth and Development in a Time Dependent Manner

Gennifer Chiou, Elysa Jui, Allison C. Rhea, Aparna Gorthi, Solaleh Miar, Francisca M. Acosta, Cynthia Perez, Yasir Suhail, Kshitiz, Yidong Chen, Joo L. Ong, Rena Bizios, Christopher Rathbone, Teja Guda

Aug 18, 2020

Cellular and Molecular Bioengineering, Volume 13

A Straightforward Approach to Engineer Vascularized Adipose Tissue Using Microvascular Fragments

Francisca M. Acosta, Katerina Stojkova, Erc M. Brey, Christopher R. Rathbone

Aug 17, 2020

Tissue Engineering Part A, Volume 26, Numbers 15-16

Stromal Cells Promote Neovascular Invasion Across Tissue Interfaces

Hannah A. Strobel, Steven A. LaBelle, Laxminarayanan Krishnan, Jacob Dale, Adam Rauff, A. Marsh Poulson IV, Nathan Bader, Jason E. Beare, Klevis Aliaj, Jeffrey A. Weiss, James B. Hoying

Aug 14, 2020

Frontiers in Physiology - Vascular Physiology

A comparative study in the printability of a bioink and 3D models across two bioprinting platforms

Matthew Alonzo, Erick Dominguez, Fabian Alvarez-Primo, Amado Quinonez, Erik Munoz, Jazmin Puebla, Antonio Barron, Luis Aguirre, Ana Vargas, Jean M. Ramirez, Binata Joddar

Apr 1, 2020

Materials Letters, Volume 264

3D Printing of Gelled and Cross-Linked Cellulose Solutions; an Exploration of Printing Parameters and Gel Behaviour

Tim Huber, Hossein Najaf Zadeh, Sean Feast, Thea Roughan, Conan Fee

Mar 27, 2020

Bioengineering, Volume 7, Edition 2

Intraoperative Bioprinting: Repairing Tissues and Organs in a Surgival Setting

Yang Wu, Dino J. Ravnic, Ibrahim T. Ozbolat

Feb 24, 2020

Trends in Biotechnology

Biofabrication of tissue perfusion systems and vasculatures

Hannah A. Strobel, Sarah M. Moss, James B. Hoying

Jan 1, 2020

Rapid Prototyping of Biomaterials - Techniques in Additive Manufacturing, Second Edition

Triggered micropore-forming bioprinting of porous viscoelastic hydrogels

Guangyu Bao, Tao Jiang, Hossein Ravanbakhsh, Alicia Reyes, Zhenwei Ma, Mitchell Strong, Huijie Wang, Joseph M. Kinsella, Jainyu Li, Luc Mongeau

Jan 1, 2020

Material Horizons, Issue 9

Insulin-like growth factor 1 stimulates the angiogenic activity of adipose tissue-derived microvascular fragments

Matthias W. Laschke, Elena Kontaxi, Claudia Scheuer, Alexander Heb, Philipp Karschnia, Michael D. Menger

Sep 27, 2019

Journal of Tissue Engineering and Regenerative Medicine, Volume 10

Characterizing the Process Physics of Ultrasound-Assisted Bioprinting

Parth Chansoria, Rohan Shirwaiker

Sep 25, 2019

Scientific Reports, Volume 9

Imaging the Dynamic Interaction Between Sprouting Microvessels and the Extracellular Matrix

Adam Rauff, Steven A. LaBelle, Hannah A. Strobel, James B. Hoying, Jeffrey A. Weiss

Aug 22, 2019

Frontiers in Physiology - Biophysics

Type I Diabetes Delays Perfusion and Engraftment of 3D Constructs by Impinging on Angiogenesis; Which can be Rescued by Hepatocyte Growth Factor Supplementation

Wafa Altalhi, Rupal Hatkar, James B. Hoying, Yasaman Aghazadeh, Sara S. Nunes

May 21, 2019

Cellular and Molecular Bioengineering, Volume 12

Large 3D bioprinted tissue: Heterogeneous perfusion and vascularization

Lea Pourchet, Emma Petiot, Celine Loubiere, Eric Olmos, Morgan Dos Santos, Amelie Thepot, Blum J. Loic, Chistophe A. Marquette

Mar 1, 2019

Bioprinting, Volume 13, Edition 39

Individual cell-only bioink and photocurable supporting medium for 3D printing and generation of engineered tissues with complex geometries

Oju Jeon, Yu Bin Lee, Hyoen Jeong, Sang Jin Lee, Derrick Wells, Eben Alsberg

Jan 1, 2019

Material Horizons, Issue 8

Subnormothermic short-term cultivation improves the vascularization capacity of adipose tissue-derived microvascular fragments

Matthias W. Laschke, Alexander Heb, Claudia Scheuer, Philipp Karschnia, Michael D. Menger

Nov 23, 2018

Journal of Tissue Engineering and Regenerative Medicine, Volume 13, Issue 2

Prevascularization of collagen-glycosaminoglycan scaffolds: stromal vascular fraction versus adipose tissue-derived microvascular fragments

Thomas Spater, Florian S. Frueh, Ruth M. Nickels, Michael D. Menger, Matthias W. Laschke

Nov 13, 2018

Journal of Biological Engineering

Effects of locally applied adipose tissue-derived microvascular fragments by thermoresponsive hydrogel on bone healing

M. Orth, M.A.B. Altmeyer, C. Scheuer, B.J. Braun, J.H. Holstein, D. Eglin, M. D'Este, T. Histing, M.W. Laschke, T. Pohlemann, M.D. Menger

Sep 1, 2018

Acta Biomaterialia, Volume 77

Prevascularization of dermal substitutes with adipose tissue-derived microvascular fragments enhances early skin grafting

Florian S. Frueh, Thomas Spater, Christina Korbel, Claudia Scheuer, Anna C. Simson, Nicole Lindenblatt, Pietro Giovanoli, Michael D. Menger, Matthias W. Laschke

Jul 20, 2018

Scientific Reports, Volume 8

Erythorpoietin promotes network formation of transplanted adipose tissue-derived microvascular fragments

P Karschnia, C Scheuer, A Heb, T Spater, M.D. Menger, M.W. Laschke

May 9, 2018

Eur Cell Mater, Volume 35

Effects of cryopreservation on adipose tissue-derived microvascular fragments

Matthias W. Laschke, Philipp Karschnia, Claudia Scheuer, Alexander Heb, Wolfgang Metzger, Michael D. Menger

Apr 1, 2018

Journal of Tissue Engineering and Regnerative Medicine, Volume 12, Issue 4

Enoxaparin does not affect network formation of adipose tissue-derived microvascular fragments

Thomas Spater, Florian S. Frueh, Philipp Karschnia, Michael D. Menger, Matthias W. Laschke

Jan 1, 2018

Wound Repair and Regeneration, Volume 26, Issue 1

Potentials and limitations of Integra® flowable wound matrix seeded with adipose tissue-derived microvascular fragments

T Spater, F.S. Frueh, M.D. Menger, M.W. Laschke

Apr 5, 2017

European Cells and Materials, Volume 33

Bioengineering cardiac constructs using 3D printing

Vahid Serpooshan, Morteza Mahmoudi, Daniel A. Hu, James B. Hu, Sean M. Wu

Mar 3, 2017

Journal of 3D Printing in Medicine, Volume 1, Number 2

Diabetes impairs arterio-venous specification in engineered vascular tissues in a perivascular cell recruitment-dependent manner

Wafa Altalhi, Xuetao Sun, Jeremy M. Sivak, Mansoor Husain, Sara S. Nunes

Mar 1, 2017

Biomaterials, Volume 119

Adipose Tissue-Derived Microvascular Fragments Improve Vascularization, Lymphangiogenesis, and Integration of Dermal Skin Substitutes

Florian S. Frueh, Thomas Spater, Nicole Lindenblatt, Maurizio Calcagni, Pietro Giovanoli, Claudia Scheuer, Michael D. Menger, Matthias W. Laschke

Jan 1, 2017

Journal of Investigative Dermatology, Volume 137, Issue 1

Seeding Density is a Crucial Determinant for the In Vivo Vascularisation Capacity of Adipose Tissue-Derived Microvascular Fragments

T. Spater, C. Korbel, F.S. Frueh, R.M. Nickels, M.D. Menger, M.W. Laschke

Jan 1, 2017

European Cells and Materials, Volume 34

Microvascular Fragment Transplantation Improves Rat Dorsal Skin Flap Survival

Randolph Stone II, Christopher R. Rathbone

Dec 23, 2016

Plastic and Reconstructive Surgery - Global Open, Volume 4, Issue 12

Effects of macrophage-activating lipopeptide-2 (MALP-2) on the vascularisation of implanted polyurethane scaffolds seeded with microvascular fragments

C. Grasser, C. Scheuer, J. Parakenings, T. Tschernig, D. Eglin, M.D. Menger, M.W. Laschke

Jul 8, 2016

European Cells and Materials, Volume 32

Vascularization strategies of engineered tissues and their application in cardiac regeneration

Xuetao Sun, Wafa Altalhi, Sara S. Nunes

Jan 15, 2016

Advanced Drug Delivery Reviews, Volume 96

Adipose tissue-derived microvascular fragments: natural vascularization units for regenerative medicine

Matthias W. Laschke, Michael D. Menger

Aug 1, 2015

Trends in Biotechnology, Volume 33, Issue 8

In Silico Investigation of Angiogenesis with Growth and Stress Generation Coupled to Local Extracellular Matrix Density

Lowell T. Edgar, James B. Hoying, Jeffrey A. Weiss

May 21, 2015

Annals of Biomedical Engineering, Volume 43

Large Scale Time Series Microscopy of Neovessel Growth During Angiogenesis

Urs Utzinger, Brenda Baggett, Jeffrey A. Weiss, James B. Hoying, Lowell T. Edgar

Mar 21, 2015

Angiogenesis, Volume 18, Issue 3

A Couple Model of Neovessel Growth and Matrix Mechanics Describes and Predicts Angiogenesis In Vitro

Lowell T. Edgar, Steve A. Maas, James E. Guilkey, Jeffrey A. Weiss

Nov 28, 2014

Biomechanics and Modeling in Mechanobiology, Volume 14

Characterization and multilineage potential of cells derived from isolated microvascular fragments

Jennifer S. McDaniel, Marcello Pilia, Catherine L. Ward, Beth E. Pollot, Christopher R. Rathbone

Nov 1, 2014

Journal of Surgical Research - Vascular, Volume 192, Issue 1

Transplantation and perfusion of microvascular fragments in a rodent model of volumetric muscle loss injury

M. Pilia, J.S. McDaniel, T. Guda, X.K. Chen, R.P. Rhoads, R.E. Allen, B.T. Corona, C.R. Rathbone

Jul 14, 2014

European Cells and Materials, Volume 28

Pericytes from Microvessel Fragment Produce Type IV Collagen and Multiple Laminin Isoforms

Hoon Jeon, Masaaki Ono, Chino Kumagai, Kiyoshi Miki, Akihito Morita, Yasuo Kitagawa

Jun 12, 2014

Bioscience, Biotechnology, and Biochemistry, Volume 60, Issue 5

Cell-generated traction forces and the resulting matrix deformation modulate microvascular alignment and growth during angiogenesis

Clayton J. Underwood, Lowell T. Edgar, James B. Hoying, Jeffrey A. Weiss

May 9, 2014

American Journal of Physiology - Heart and Circulatory Physiology

Mechanical Interaction of Angiogenic Microvessels with the Extracellular Matrix

Lowell T. Edgar, James B. Hoying, Urs Utzinger, Clayton J. Underwood, Laxminarayanan Krishnan, Brenda K. Baggett, Steve A. Maas, James E. Guilkey, Jeffrey A. Weiss

Feb 5, 2014

Journal of Biomechanical Engineering, Volume 136, Issue 2

Extracellular Matrix Density Regulates the Rate of Neovessel Growth and Branching in Sprouting Angiogenesis

Lowell T. Edgar, Clayton J. Underwood, James E. Guilkey, James B. Hoying, Jeffrey A. Weiss

Jan 22, 2014

PLoS One

Hypoxia Simultaneously Alters Satellite Cell-Mediate Angiogensis and Hepatocyte Growth Factor Expression

K.L. Flann, C.R. Rathbone, L.C. Cole, X. Liu, R.E. Allen, R.P. Rhoads

Oct 5, 2013

Journal of Cellular Phyisology, Volume 229, Issue 5

Vascularisation of porous scaffolds is improved by incorporation of adipose tissue-derived microvascular fragments

M.W. Laschke, S. Kleer, C. Scheuer, S. Schuler, P. Garcia, D. Eglin, M. Alini, M.D. Venger

Dec 1, 2012

European Cells and Materials, Volume 24

A Computational Model of In Vitro Angiogenesis based on Extracellular Matrix Fiber Orientation

Lowell T. Edgar, Scott C. Sibole, Clayton J. Underwood, James E. Guilkey, Jeffrey A. Weiss

Apr 19, 2012

Computer Methods in Biomechanics and Biomedical Engineering, Volume 16, Issue 7

Engineering fibrin polymers through engagement of alternative polymerization mechanisms

Sarah E. Stabenfeldt, Merek Gourley, Laxminarayanan Krishnan, James B. Hoying, Thomas H. Barker

Jan 1, 2012

Biomaterials, Volume 33, Issue 2

Vessel Arterial-Venous Plasticity in Adult Neovascularization

Sara S. Nunes, Harish Rekapally, Carlos C. Chang, James B. Hoying

Nov 21, 2011

PLoS One

Determinants of Microvascular Network Topolgies in Implanted Neovasculatures

Carlos C. Chang, Laximarayanan Krishnan, Sara S. Nunes, Kenneth H. Church, Lowell T. Edgar, Eugene D. Boland, Jeffrey A. Weiss, Stuart K. Williams, James B. Hoying

Nov 3, 2011

Arteriosclerosis, Thrombosis, and Vascular Biology, Volume 32

Implanted Microvessels Progress through Distinct Neovascularization Phenotypes

Sara S. Nunes, Kevin A. Greer, Chad M. Stiening, Helen YS. Chen, Kameha R. Kidd, Mark A. Schwartz, Chris J. Sullivan, Harish Rekapally, James B. Hoying

Jan 1, 2011

Microvascular Research, Volume 79, Issue 1

Angiogenic potential of microvessel fragments is independent of the tissue of origin and can be influenced by the cellular composition of the implants

Sara S. Nunes, Laxminarayanan Krishnan, Carter S. Gerard, Jacob R. Dale, Melissa A. Maddie, Richard L. Benton, James B. Hoying

Oct 17, 2010

Microcirculation, Volume 17, Issue 7

Encapsulation of ePTFE in prevascularized collagen leads to peri-implant vascularization with reduced inflammation

Gabriel Gruionu, Alice L. Stone, Mark A. Schwartz, James B. Hoying, Stuart K. Williams

Aug 23, 2010

Journal of Biomedical Materials Research Part A, Volume 95A, Issue 3

Microvascular Transplantation After Acute Myocardial Infarction

Benjamin R. Shepherd, James B. Hoying, Stuart K. Williams

Jan 17, 2010

Advances in Tissue Engineering, Volume 1 - Angiogenesis

Angiogenesis in a Microvascular Construct for Transplantation Depends on the Method of Chamber Circulation

Carlos C. Chang, Sara S. Nunes, Scott C. Sibole, Laxminarayanan Krishnan, Stuart K. Williams, Jeffrey A. Weiss, James B. Hoying

Dec 18, 2009

Tissue Engineering Part A, Volume 16, Number 3

Satellite cell-mediated angiogenesis in vitro coincides with a functional hypoxia-inducible factor pathway

R.P. Roads, R. M. Johnson, C.R. Rathbone, X. Liu, C. Temm-Grove, S.M. Sheehan, James B. Hoying, R.E. Allen

Jun 1, 2009

American Journal of Physiology - Cell Physiology

An Islet-Stabilizing Implant Constructed Using a Preformed Vasculature

Alton M. Hiscox, Alice L. Stone, Sean Limesand, James B. Hoying, Stuart K. Williams

Mar 11, 2008

Tissue Engineering Part A, Volume 14, Number 3

Effect of Mechanical Boundary Conditions on Orientation of Angiogenic Microvessels

Laxminarayanan Krishnan, Clayton J. Underwood, Steve Maas, Benjamin J. Ellis, Tejas C. Kode, James B. Hoying, Jeffrey A. Weiss

Feb 28, 2008

Cardiovascular Research, Volume 78, Issue 2

Interaction of Angiogenic Microvessels with the Extracellular Matrix

Laxminarayanan Krishnan, James B. Hoying, Hoa Nguyen, Helen Song, Jeffrey A. Weiss

Oct 12, 2007

American Journal of Physiology - Heart and Circulatory Physiology

Live imaging of collagen remodeling during angiogenesis

Nathaniel D. Kirkpatrick, Stylianos Andreou, James B. Hoying, Urs Utzinger

Jun 1, 2007

American Journal of Physiology - Heart and Circulatory Physiology

Directed Three-Dimensional Gowth of Microvascular Cells and Isolated Microvessel Fragments

Carlos C. Chang, James B. Hoying

Mar 1, 2006

Cell Transplantation, Volume 15

The non-proteolytically active thrombin peptide TP508 stimulates angiogenic sprouting

Keri B. Vartanian, Helen Y.S. Chen, Janelle Kennedy, Shaleen K. Beck, James T. Ryaby, Hali Wang, James B. Hoying

Jul 14, 2005

Journal of Cellular Phyisology, Volume 206, Issue 1

Rapid Perfusion and Network Remodeling in a Microvascular Construct After Implantation

Benjamin R. Shepherd, Helen Y.S. Chen, Cynthia M. Smith, Gabriel Gruionu, Stuart K. Williams, James B. Hoying

Feb 26, 2004

Arteriosclerosis, Thrombosis, and Vascular Biology, Volume 24

Parathyroid-induced angiogenesis is VEGF-dependent

W. Bradford Carter, Kenny Uy, Michael D. Ward, James B. Hoying

Sep 1, 2000

Surgery, Volume 128, Issue 3

Successful Autotransplantation of Microvessel Fragments into the Rat Heart

M. Nakano, Y. Nakajima, S. Kudo, Y. Tsuchida, H. Nakamura, O. Fukuda

Jan 1, 1999

Eurpoean Surgical Research, Volume 31

Effect of autotransplantation of microvessel fragments on experimental random-pattern flaps in the rat

M. Nakano, Y. Nakajima, S. Kudo, Y. Tsuchida, H. Nakamura, O. Fukuda

Jan 1, 1998

European Surgical Research, Volume 30

Direct evidence of a connection between autotransplanted microvessel fragments and the host microvascular system

M. Nakano, Y. Nakajima, S. Kudo, Y. Tsuchida, H. Nakamura, O. Fukuda

Jul 1, 1997

International Journal of Microcirculation, Volume 17

Angiogenic potential of microvessel fragments established in three-dimensional collagen gels

James B. Hoying, Carl A. Boswell, Stuart K. Williams

Jul 1, 1996

In Vitro Cellular & Developmental Biology - Animal, Volume 32