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The solution for vascularizing tissue.

Angiomics Microvessels enables better biology outcomes with 3D tissue and organoid assays by creating more native-like tissue environments due to the complex, pro-tissue cell composition of the isolated microvessels that promote stable vascularization and parenchyma function. The integration of a perfused, bona fide microcirculation in the tissue systems model further support tissue function and models tissue and blood exchange as it occurs in the body.

 

Whole Microvessels from Human Adipose Tissues.

Angiomics is a patented human vascularization platform designed for 3D tissue and organoid construction for both in vivo and in vitro applications. Angiomics utilizes a whole microvessel harvesting process from human adipose tissue. The pieces of intact human adipose Microvessels (haMVs) are then induced to undergo angiogenesis and build adaptable, intact perfusable microvasculatures to support a given 3D tissue system.

Recapitulate Native Angiogenesis and Vascularization

Microvessels
Marker
% of Cells in Microvessel
F4/80
23.60%
CD2
0.80%
Sca-1
11.40%
Gr-1
5.10%
CD146
28.20%
CD34
26.70%
Tie2
21.00%

In a single haMV isolate, pieces of intact microvessels provide all vascular cells necessary to recapitulate native vascularization.

Human Microvessels.

Angiomics hamV are intact microvessels that are frozen in aliquots after a certified harvesting process and shipped in frozen cryovials. The Angiomics hamV can be integrated into a tissue model with a variety of cells, 3D tissues and organoid assays to promote parenchyma performance resulting in better biological outcomes.

Backed by more than 50 peer-reviewed publications since 1996, the Angiomics hamV has been successfully researched and applied in angiogenesis dynamics, angiogenesis and tissue biomechanics, microvascular biology in health and disease, tissue vascularization and graft/implant vascularization.

Microvessel diagram

50-200µ in Length 

10-50µ in Diameter

 

Repair Tissue.

Achieve rapid inosculation and perfusion with implant-site vasculature that adapts, remodels, and repairs.

Model Diseases.

From organotypic microvasculatures via phenotypic plasticity and adaptability.

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Angiogenesis Assays.

Build adaptable and mature microcirculations.

Our unique approach to vascularizing tissue:

Recapitulate angiogenesis within a wide variety of 3D culture environments.
cryovials

Integration

Microvessel vials are thawed and pipetted or bioprinted into 3D cell culture.

Neovessels sprout from parents and retain lumens.

Incubation

Inosculation at Advanced Solutions

Inosculation

Growing vessels inosculate, establishing a perfusable microvasculature.

 

Angiomics Key Features & Specifications:

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Native & Intact Human Microvessels

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Full Complement of

Microvascular Cells

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Phenotypically Plastic & Dynamic with the Tissue Environment

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Parenchyma/Stromal Cell

Microvessel Cooperativity 

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Recapitulates Vascularization

30+ Years

of Tissue Vascularization

Expertise and Support

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Use with BioBot Basic, BioAssemblyBots 200, 400, & 500

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Use with BioStorageBot Benchtop

Incorporates with:

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Preparation & Packaging:

Vials are frozen at the time of isolation and stored in liquid nitrogen

Growth Potential:

Each microvessel lot is qualified for positive neovessel growth activity

Microvessel Source:

Microvessels are isolated from subcutaneous adipose.

Microvessels are isolated from donated human tissue for use in research by informed consent or legal authorization. Age and sex of donor are provided with each lot. 

Available Sizes:

20K, 50K, or 100K microvessels/vial

Angiomics Human Adipose Microvessels by Advanced Solutions are for RESEARCH USE ONLY and not for use in humans under any circumstances. Advanced Solutions Life Sciences, LLC. and Advanced Solutions, Inc. are not responsible or liable for how this product is used. The RESEARCH USE ONLY limitation supersedes any written, oral, or implied understanding between the parties.

 
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Angiomics Human Adipose Microvessels by Advanced Solutions are for RESEARCH USE ONLY and not for use in humans under any circumstances. Advanced Solutions Life Sciences, LLC. and Advanced Solutions, Inc. are not responsible or liable for how this product is used. The RESEARCH USE ONLY limitation supersedes any written, oral, or implied understanding between the parties.

UL Certified Badge

The Advanced Solutions Louisville, KY facility has been audited by UL Registrar LLC and meets GMP requirements listed in RCP, NBCP, or Pharmaceutical Certification Schemes which is uniquely accredited by the American National Standard Institute (ANSI) developed in accordance with applicable sections of the FDA’s code of federal regulations.