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Advanced Solutions Angiomics™ platform providing engineered vascularized microtissues for enhanced 3D organoid perfusion, dru

A Genuine Vascularization Solution

Better Biology by vascularizing your human-relevant models with ready to

use, isolated human microvessels. 

Our Angiomics® microvessels are cryopreserved fragments of intact human microvessels (haMVs) recapitulating native microvascular biology and boosting physiological relevance to any 3D model. Use haMVs in existing, validated protocols or develop your own to integrate native microvasculatures into your cell and tissue models thereby enhancing discovery and redictability. Qualified for consistent performance, our haMVs combine microvascular cell complexity in a single reagent ready for immediate use. Realize better results by modeling

better biology with haMV vascularization.

Overview

Angiomics®
Human Microvessels

Different from just endothelial cells, Angiomics® haMVs are fragments of intact microvessels that are frozen in aliquots after a certified harvesting process and shipped in frozen cryovials. Our proprietary harvest process keeps intact the structure and cell composition of the native microvessel, including those cells residing in the perivascular niche.

 

When added to a 3D tissue or organoid model, such as the human vascularized MVP LIVER™ tissue model, the Angiomics® haMVs contribute to the tissue-specific environment, adding relevant and important complexity for better biological outcomes. Advance your research with a native microcirculation with the haMV-based Vascularized In Vitro Perfusion Model (VIPM) microphysiological system. Backed by decades of peer-reviewed research and comprehensive support, leverage Angiomics® haMVs to model angiogenesis, model vascularized tumor microenvironments, vascularize organoids/microtissues, and model perfused microphysiological systems

haMV vs EC figure.png

The presence of the Angiomics microvessels enabled more predictive treatment outcomes for in vitro cancer models.

Recapitulate Native Angiogenesis and Vascularization

Engineered microvessels forming interconnected vascular networks to support nutrient and oxygen delivery in 3D tissue constru
Marker
% of Cells in Microvessel
F4/80
23.60%
CD2
0.80%
Sca-1
11.40%
Gr-1
5.10%
CD146
28.20%
CD34
26.70%
Tie2
21.00%

In a single haMV isolate, pieces of intact microvessels provide all vascular cells necessary to recapitulate native vascularization.

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Tissue Vascularization

Tumor

Microenvironment

Vascularized 

Organoids

Microphysiological Systems

Human Microvessels.

Angiomics hamV are intact microvessels that are frozen in aliquots after a certified harvesting process and shipped in frozen cryovials. The Angiomics hamV can be integrated into a tissue model with a variety of cells, 3D tissues and organoid assays to promote parenchyma performance resulting in better biological outcomes.

Backed by more than 50 peer-reviewed publications since 1996, the Angiomics hamV has been successfully researched and applied in angiogenesis dynamics, angiogenesis and tissue biomechanics, microvascular biology in health and disease, tissue vascularization and graft/implant vascularization.

Diagram illustrating the structure of engineered microvessels, highlighting endothelial cells forming capillary networks for

50-200µ in Length 

10-50µ in Diameter

Applications

Vascularize with Confidence

Protocols for using haMVs are provided with each vial and scientific expertise is available to support your vascularization outcomes.

Model Diseases.

Combine with the BioAssemblyBot® and BioApps® Platforms to automate your vascularized tissue modeling and assaying in order to save time, reduce costs, and streamline your research. 

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Ready for immediate use

Our haMVs are delivered frozen in standard vials containing different numbers of microvessels tailored for different applications. Thaw and use the microvessels however you would use cells to vascularize your models. 

Our unique approach to vascularizing tissue:

Recapitulate angiogenesis within a wide variety of 3D culture environments.
Cryovials containing cryopreserved cell samples for long-term storage and preservation in regenerative medicine workflows.

Integration

Microvessel vials are thawed and pipetted or bioprinted into 3D cell culture.

Neovessels sprout from parents and retain lumens.

Incubation

Advanced Solutions demonstrating inosculation—the natural fusion of vascular networks—in engineered tissues to enhance perfus

Inosculation

Growing vessels inosculate, establishing a perfusable microvasculature.

Process

Angiomics Key Features & Specifications:

Native & Intact Human Microvessels

Native Human Microvessels 

Full Complement of  Microvascular Cells

Full Complement of

Microvascular Cells

Phenotypically Plastic & Dynamic with the Tissue Environment

Phenotypically Plastic & Dynamic with the Tissue Environment

Parenchyma/Stromal Cell  Microvessel Cooperativity

Parenchyma/Stromal Cell

Microvessel Cooperativity 

Recapitulates Vascularization

Recapitulates In Vivo Vascularization

30+ Years

of Tissue Vascularization

Expertise and Support

* BioAssemblyBot 400 with integrated smart sensors and interchangeable tools for scalable and reproducible biofabrication.

Use with BioAssemblyBots 200, 400, & 500

Use with BioStorageBot Benchtop

Use with BioStorageBot Benchtop

Incorporates with:

Incorporates to bioapps

Preparation & Packaging:

Vials are frozen at the time of isolation and stored in liquid nitrogen

Growth Potential:

Each microvessel lot is qualified for positive neovessel growth activity

Microvessel Source:

Microvessels are isolated from subcutaneous adipose.

Microvessels are isolated from donated human tissue for use in research by informed consent or legal authorization. Age and sex of donor are provided with each lot. 

Available Sizes:

20K, 50K, or 100K microvessels/vial

Angiomics Human Adipose Microvessels by Advanced Solutions are for RESEARCH USE ONLY and not for use in humans under any circumstances. Advanced Solutions Life Sciences, LLC. and Advanced Solutions, Inc. are not responsible or liable for how this product is used. The RESEARCH USE ONLY limitation supersedes any written, oral, or implied understanding between the parties.

Tech Specs
Microvessel isolate sample containing purified vascular microtissues for incorporation into 3D engineered tissue and organoid
Advanced Solutions Angiomics™ platform providing engineered vascularized microtissues for enhanced 3D organoid

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Angiomics Human Adipose Microvessels by Advanced Solutions are for RESEARCH USE ONLY and not for use in humans under any circumstances. Advanced Solutions Life Sciences, LLC. and Advanced Solutions, Inc. are not responsible or liable for how this product is used. The RESEARCH USE ONLY limitation supersedes any written, oral, or implied understanding between the parties.

* UL mark alongside CE and other regulatory symbols, denoting international compliance for use in biomedical research facilit

The Advanced Solutions Louisville, KY facility has been audited by UL Registrar LLC and meets GMP requirements listed in RCP, NBCP, or Pharmaceutical Certification Schemes which is uniquely accredited by the American National Standard Institute (ANSI) developed in accordance with applicable sections of the FDA’s code of federal regulations.

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