Dr. Vahid Serpooshan, at Emory/Georgia Tech University, recently published work on the biofabrication of bacteriostatic bone constructs with in vivo regenerative capacity. In this publication, featured on the cover of Polymers (pictured above), the BioAssemblyBot® platform was used to print a disc shape (3.5mm x 0.9mm) and a cylinder shape (3.5mm x 9mm) for in vitro and in vivo analysis, respectively. The constructs were fabricated using hyperelastic bone (produced by Dimension Inx), where material characteristics and functional assessment was compared between superparamagnetic iron oxide nanoparticle (SPION) loaded or SPOIN-free material. SPION-loaded scaffolds demonstrated a smoother surface structure, retained a high degree of elasticity, significantly increased the compressive modulus in the cylinder shape, and demonstrated higher viability of murine and human seeded cells in vitro compared with SPION-free scaffold. The SPION-loaded HB scaffold also demonstrated adequate engraftment in vivo while importantly showing no signs of infection.
Read more: https://www.mdpi.com/2073-4360/13/7/1099
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