Human Heart Recellularization with Dr. Doris Taylor Get Started Create a personalized human heart replacement. BioAssemblyBot® (#WeCallHerBAB) now offers a way to robotically add patient stem cells back to a decellularized heart and bring it back to life. Transfer processes to close and automate them. When we eliminate human interaction and contamination, new speeds and possibilities are within reach. First Bioengineered Human Heart Dr. Doris Taylor, CEO and founder of Organamet Bio, shows off her ground-breaking process for creating the World’s first bioengineered human heart. Dr. Taylor is teaching BAB her recellularization techniques in order to provide a quicker transition of her research into a clinical setting. Her talk took place on stage at the 2022 Life Itself conference, a health event presented in partnership with CNN. BAB learns complex processes. Dr. Doris Taylor taught BAB to her method of injecting 350 billion cells into a heart scaffold, enabling the automation and creation of a personalized human heart fast enough to realistically enable on-demand bio-engineered human heart transplants. Increase Availability and Access. With ready-made heart replacements, gone are the days of waiting on a transplant list. Eliminate Immunosuppression. Built from an individual’s own cells, the bio-engineered heart replacement won't be rejected and without the use of antirejection medication. Reduce Total Transplant Costs. By creating a heart from scratch, a transplant does not mean trading one life for another. Plan Heart Transplants. Unlike traditional heart transplants, if you know you have a problem, you don't need to wait for an emergency to receive a transplant. Plan and schedule a transplant proactively. Get Quote Learn More Get Quote Learn More Get Quote Learn More Applications Show All Hide All Academic (College) Research & Development Pharma _ Academic (College) Research & Development Pharma _ Academic (College) Research & Development Pharma Clinical Features Build simple to moderately complex disease models 3D Additive Models Great Identify new molecular targets Good Develop new drugs 3D Print in Well Plates 4-axis Robot Biosafety Cabinet Compatible (without enclosure) HEPA Filtration Optional Build simple to highly complex disease models 3D Additive & Contour Models Great Identify new molecular targets Great Develop new drugs 3D Print in Well Plates 6-axis Robot _ HEPA Filtration Optional Build simple to highly complex disease models 3D Additive & Contour Models Great Identify new molecular targets Great Develop new drugs 3D Print in Well Plates 6-axis Robot Integrated Class II, Type A Biosafety Cabinet Integrated HEPA Filtration Certifications TSIM Certified BioApps Certified UL cGMP Certified UL/CE Certification in progress TSIM Certified BioApps Certified UL cGMP Certified UL/CE Certified TSIM Certified BioApps Certified UL cGMP Certified UL/CE Certification in progress Integrations Up to 5 BioAssemblyBot Hands in a single run Good Agile integration with other lab equipment Up to 8 BioAssemblyBot Hands in a single run Great* Agile integration with other lab equipment Up to 10 BioAssemblyBot Hands in a single run Great* Agile integration with other lab equipment *Requires BioBot Link Get Quote Learn More Get Quote Learn More Get Quote Learn More What researchers use with BAB: Buy Now Learn More Get Started Learn More Get Quote Learn More Get Quote Learn More View All Products Explore more solutions: 3D Bioprinting Bioprint in ways you never thought possible. See This Solution Organoids/ Spheroids One platform, better outcomes. See This Solution Vascularization Bring your tissue to life. See This Solution Ready to get started? Connect with a recellularization expert: Email Alert Message Join the Community to receive periodic updates on advancements with Advanced Solutions Thanks! We'll be in touch soon! Submit > The BioAssemblyBot 400 is certified by UL in accordance with applicable safety requirements. The BioAssemblyBot 400 is certified by UL in accordance with applicable energy efficiency requirements. ​ The Advanced Solutions Louisville, KY facility has been audited by UL Registrar LLC and meets GMP requirements listed in RCP, NBCP, or Pharmaceutical Certification Schemes which is uniquely accredited by the American National Standard Institute (ANSI) developed in accordance with applicable sections of the FDA’s code of federal regulations. 3ATM Quote

Get Quote 3D Syringe | 30ml Pneumatic Dispense Overview Advanced Solutions’ 3D Syringe is an ambient extrusion printhead for use with BioAssemblyBot®. Simple, powerful, and rigorously tested for quality, this printhead is best used with bioinks that do not require thermal or cooled conditions. Example materials including hydrogels, pastes, cells and other ambient bioinks. Features Multi-axis 3D printhead maintains cell viability through the printing process Quick-release clamp enables easy & clean loading Ideal for non-temperature sensitive biomaterials Automated tip detection & calibration Seamlessly 3D bioprints with TSIM software, or include an in automated biofabrication workflow with BioApps Compatibility BioAssemblyBot 200, BioAssemblyBot 400, BioAssemblyBot 500 ASLS-0000101 (30 mL) Recommended 3D Syringe | 500ml Pneumatic Dispense Learn More 3D Dual Syringe Pneumatic Dispense Learn More 3D Syringe | UV Pneumatic Dispense Learn More

Get Quote 3D Syringe | 100ml Pneumatic Dispense Overview Advanced Solutions’ 3D Syringe is an ambient extrusion printhead for use with BioAssemblyBot®. Simple, powerful, and rigorously tested for quality, this printhead is best used with bioinks that do not require thermal or cooled conditions. Example materials including hydrogels, pastes, cells and other ambient bioinks. Features Multi-axis 3D printhead maintains cell viability through the printing process Quick-release clamp enables easy & clean loading Ideal for non-temperature sensitive biomaterials Automated tip detection & calibration Seamlessly 3D bioprints with TSIM software, or include an in automated biofabrication workflow with BioApps Compatibility BioAssemblyBot 400, BioAssemblyBot 500 ASLS-0000248 Recommended 3D Syringe | 500ml Pneumatic Dispense Learn More 3D Syringe | 3/5/10ml Pneumatic Dispense Learn More 3D Syringe | 30ml Pneumatic Dispense Learn More

Discover Your Own Get Started What is a BAB solution? Let's walk through what BAB can do for you... Uniquely engineered for 3D bioprinting. Transform your biomedical research with cutting-edge automation and precision. BioAssemblyBot Solutions revolutionize the way you conduct experiments, offering unparalleled flexibility, accuracy, and efficiency. Whether you're exploring tissue engineering, drug discovery, regenerative medicine, or cellular therapies, BioAssemblyBot Solutions empower you to push the boundaries of science and unlock new possibilities in your lab. The Perfect Blend. Workflows Automation Platform Incubation Can I get a hand? Choose from a rich and continuously expanding library of BAB Hands or build your own Hand to accomplish your 3D bioprinting objectives. BAB Hands enable you to print a variety of materials at different temperatures and combinations, fully automate the printing and analytical tasks, locally inject and deposit cells in and on tissue constructs, and conduct scientific experiments with 3D bioprinting. More tools means more capability, more flexibility, and more innovation. Explore BioAssemblyBot Hands Buy Now Learn More Get Quote Learn More Get Quote Learn More Get Quote Learn More Applications Show All Hide All Academic (High School & College) _ _ _ Academic (College) Research & Development Pharma _ Academic (College) Research & Development Pharma _ Academic (College) Research & Development Pharma Clinical Features 3D Additive Printing _ 3-axis Robot Biosafety Cabinet Compatible _ 3D Additive Models ​ ​ 3D Print in Well Plates ​ 4-axis Robot ​ Biosafety Cabinet Compatible (without enclosure) ​ HEPA Filtration Optional 3D Additive & Contour Printing 3D Print in Well Plates 6-axis Robot _ HEPA Filtration Optional 3D Additive & Contour Printing ​ 3D Print in Well Plates ​ 6-axis Robot ​ Integrated Class II, Type A Biosafety Cabinet ​ ​ Integrated HEPA Filtration Certifications TSIM Certified ​ _ ​ UL cGMP Certified ​ _ ​ TSIM Certified ​ BioApps Certified ​ UL cGMP Certified ​ UL/CE Certification in progress TSIM Certified ​ BioApps Certified ​ UL cGMP Certified ​ UL/CE Certified TSIM Certified BioApps Certified UL cGMP Certified UL/CE Certification in progress Integrations Up to 5 ambient 10ml syringes in a single run ​ Good Agile integration with other lab equipment Up to 5 BioAssemblyBot Hands in a single run ​ Good Agile integration with other lab equipment Up to 8 BioAssemblyBot Hands in a single run ​ Great Agile integration with other lab equipment Up to 10 BioAssemblyBot Hands in a single run Great* Agile integration with other lab equipment *Requires BioBot Link Buy Now Learn More Get Quote Learn More Get Quote Learn More Get Quote Learn More What 3D bioprinting experts use with BAB: Buy Now Learn More 3D Dual Syringe Get Quote Learn More 3D Dual Syringe | Coaxial Get Quote Learn More 3D Syringe | UV Get Quote Learn More View All Products Explore more solutions: Advanced 3D Tissue Models Mimic human tissues by capturing more of the native biology. See This Solution Organoids/ Spheroids One platform, better outcomes. See This Solution Vascularization Bring your tissue to life. See This Solution Ready to get started? Connect with an 3D Bioprinting expert: Email Alert Message Join the Community to receive periodic updates on advancements with Advanced Solutions Thanks! We'll be in touch soon! Submit > 3DBioQuote The BioAssemblyBot 400 is certified by UL in accordance with applicable safety requirements. The BioAssemblyBot 400 is certified by UL in accordance with applicable energy efficiency requirements. ​ The Advanced Solutions Louisville, KY facility has been audited by UL Registrar LLC and meets GMP requirements listed in RCP, NBCP, or Pharmaceutical Certification Schemes which is uniquely accredited by the American National Standard Institute (ANSI) developed in accordance with applicable sections of the FDA’s code of federal regulations.

3D Bioprinting 3D Bioprinting BAB is the most advanced, versatile, intelligent 3D bioprinter on planet Earth. Learn More Human Heart Recellularization with Dr. Doris Taylor The future of on-demand human hearts with Dr. Taylor. Human Heart Recellularization Learn More Vascularization Vascularization Make your tissue models complete with native vascular perfusion solutions. Learn More Advanced 3D Tissue Models Mimic human tissues by capturing the native biology. Advanced 3D Tissue Models Learn More Organoids/ Spheroids Build and handle all types and sizes without damage. Organoids/ Spheroids Learn More Do more with BioAssemblyBot... Do more 3D bioprinting with BioAssemblyBot... Do more organoids/spheroids with BioAssemblyBot... Do more advanced 3D tissue models with BioAssemblyBot... Do more vascularization with BioAssemblyBot... Do more heart recellularization with BioAssemblyBot... Do more hsingle cell dispense with BioAssemblyBot... B ioA ssemblyB ot (#WeCallHerBAB) The patented, UL and cGMP certified, award-winning BioAssemblyBot platform is an intelligent agile robotic system used to build and assemble biological structures. More than a 3D printer, BAB, as we call her, leverages over 60 years of industrial robotic innovation to bring speed, quality, high precision and low cost manufacturing to the task of building tissues and organs. Meet BAB Extraordinary discoveries. Latest news BAB Empowers Breast Cancer Survivors BAB Meets Dr. Doris Taylor BAB Featured at 'Life Itself' BioBots BioBot Basic BioAssemblyBot 200 BioAssemblyBot 400 BioAssemblyBot 500 BioAssemblyBot Hands BioStorageBot Benchtop Software TSIM BioSegment BioApps BioApps Maker Angiomics Microvessels VIPM PerFuseIt Trusted by drug discoverers, tissue engineers, device developers, and researchers. "BioAssemblyBot and Angiomics biofabrication platforms are valuable inventions and contributions toward our ARMI mission to mass produce human organs. Advanced Solutions is the poster child company for the ARMI ecosystem. The team is entrepreneurial, talented, and leading members for ARMI." Dean Kamen, Executive Director of ARMI What are your bioassembly needs? Our biofabrication experts are ready to talk to you. Interest* Join the Community to receive periodic updates on advancements with Advanced Solutions Thanks! We'll be in touch soon. Submit > The BioAssemblyBot 400 is certified by UL in accordance with applicable safety requirements. The BioAssemblyBot 400 is certified by UL in accordance with applicable energy efficiency requirements. ​ The Advanced Solutions Louisville, KY facility has been audited by UL Registrar LLC and meets GMP requirements listed in RCP, NBCP, or Pharmaceutical Certification Schemes which is uniquely accredited by the American National Standard Institute (ANSI) developed in accordance with applicable sections of the FDA’s code of federal regulations.

Get Quote 3D Syringe | UV Pneumatic Dispense Overview Advanced Solutions’ 3D Syringe | UV enables users to easily 3D bioprint photocurable biomaterials such as methacrylated materials. Utilizing BioApps™ software, BAB users can easily & quickly define UV curing pathways into their biofabrication workflows to occur during extrusion or as a post-processing step. Our UV Disinfection tool can be used before a print to ensure sterility (along with our BAB Sterilization Protocol) of the build environment. Features Pneumatic extrusion-based, multi-axis 3D bioprinthead enables bioprinting with materials that require light based crosslinking Quick-release barrel holder enables easy & clean loading of biomaterials Maintains temperature throughout workflow – including on-bay and during printing Ideal for 3D printing UV curable biomaterials including such as GelMA UV wavelengths of 365nm or 405nm Compatible with 30-mL syringe barrels Seamlessly control temperature, 3D bioprint, and crosslink the material with TSIM® software, or include an in automated biofabrication workflow with BioApps™ Compatibility BioAssemblyBot 400 ASLS-0000107 (30 mL) Recommended 3D Syringe | Hot Pneumatic Dispense Learn More 3D Dual Syringe | Coaxial Pneumatic Dispense Learn More 3D Syringe | Cold Pneumatic Dispense Learn More

Single Cell Dispense Get Started Paving the way for medical breakthroughs and deeper understanding, one cell at a time. Discover Single Cell Dispense on BioAssemblyBot To extend BAB's capabilities, we've introduced the BioAssemblyBot® Hand | SCD for single cell dispensing. With this innovative solution, researchers can rapidly dispense single cells into various plates and containers, seamlessly integrating this activity into larger, autonomous workflows. Coupled with BAB's BioApp™ platform, researchers can generate comprehensive reports on workflow operations and clonality, enhancing the efficiency and reliability of their experiments. View Application Note Streamlined Workflow. Welcome to the future of laboratory efficiency. Our Single Cell Dispensing technology is redefining the way researchers approach their experiments. By automating the precise dispensing of single cells, we're streamlining laboratory workflows like never before. Say goodbye to labor-intensive pipetting tasks and hello to a new era of efficiency and reliability. With our solution seamlessly integrated into your existing workflows, you can focus on the science while we handle the rest. Experience the transformative power of Single Cell Dispensing with Advanced Solutions Life Sciences.. Enhanced Accuracy. BAB leverages impedance measurements and monitoring to dispense single cells from a cell suspension into multi-well plates and containers. With the intuitive software interface of BioApps™, researchers can translate protocols into automation commands, enabling real-time reporting of plating efficiencies, impedance measurements, operation timings, and imaging results. Unparalleled Efficiency Rate. Dispense microspheres/cells with high efficiency and reliability, real-time reporting by BAB of each dispense event shown to produce 97% for microspheres and 92% for cells. Applications Gene Editing : Facilitate gene editing experiments by precisely dispensing single cells into multi-well plates. Cell Line Development : Accelerate cell line development processes by automating the dispensing of single cells for clonal expansion. Antibody Development : Improve antibody development workflows by ensuring clonality and reliability in cell-based assays. . Can I get a hand? Choose from a rich and continuously expanding library of BAB Hands or build your own Hand to accomplish your 3D bioprinting objectives. BAB Hands enable you to print a variety of materials at different temperatures and combinations, fully automate the printing and analytical tasks, locally inject and deposit cells in and on tissue constructs, and conduct scientific experiments with 3D bioprinting. More tools means more capability, more flexibility, and more innovation. Explore BioAssemblyBot Hands Buy Now Learn More Get Quote Learn More Get Quote Learn More Get Quote Learn More Applications Show All Hide All Academic (High School & College) _ _ _ Academic (College) Research & Development Pharma _ Academic (College) Research & Development Pharma _ Academic (College) Research & Development Pharma Clinical Features 3D Additive Printing _ 3-axis Robot Biosafety Cabinet Compatible _ 3D Additive Models ​ ​ 3D Print in Well Plates ​ 4-axis Robot ​ Biosafety Cabinet Compatible (without enclosure) ​ HEPA Filtration Optional 3D Additive & Contour Printing 3D Print in Well Plates 6-axis Robot _ HEPA Filtration Optional 3D Additive & Contour Printing ​ 3D Print in Well Plates ​ 6-axis Robot ​ Integrated Class II, Type A Biosafety Cabinet ​ ​ Integrated HEPA Filtration Certifications TSIM Certified ​ _ ​ UL cGMP Certified ​ _ ​ TSIM Certified ​ BioApps Certified ​ UL cGMP Certified ​ UL/CE Certification in progress TSIM Certified ​ BioApps Certified ​ UL cGMP Certified ​ UL/CE Certified TSIM Certified BioApps Certified UL cGMP Certified UL/CE Certification in progress Integrations Up to 5 ambient 10ml syringes in a single run ​ Good Agile integration with other lab equipment Up to 5 BioAssemblyBot Hands in a single run ​ Good Agile integration with other lab equipment Up to 8 BioAssemblyBot Hands in a single run ​ Great Agile integration with other lab equipment Up to 10 BioAssemblyBot Hands in a single run Great* Agile integration with other lab equipment *Requires BioBot Link Buy Now Learn More Get Quote Learn More Get Quote Learn More Get Quote Learn More What 3D bioprinting experts use with BAB: Buy Now Learn More 3D Dual Syringe Get Quote Learn More 3D Dual Syringe | Coaxial Get Quote Learn More 3D Syringe | UV Get Quote Learn More View All Products Explore more solutions: Advanced 3D Tissue Models Mimic human tissues by capturing more of the native biology. See This Solution Organoids/ Spheroids One platform, better outcomes. See This Solution Vascularization Bring your tissue to life. See This Solution Ready to get started? Connect with an 3D Bioprinting expert: Email Alert Message Join the Community to receive periodic updates on advancements with Advanced Solutions Thanks! We'll be in touch soon! Submit > SCDQuote The BioAssemblyBot 400 is certified by UL in accordance with applicable safety requirements. The BioAssemblyBot 400 is certified by UL in accordance with applicable energy efficiency requirements. ​ The Advanced Solutions Louisville, KY facility has been audited by UL Registrar LLC and meets GMP requirements listed in RCP, NBCP, or Pharmaceutical Certification Schemes which is uniquely accredited by the American National Standard Institute (ANSI) developed in accordance with applicable sections of the FDA’s code of federal regulations.

Explore Tools Get Quote Explore Tools Find the BAB Hand that is perfect for you! BAB Compatibility: Application Type: Solution: 3D Dual Syringe Learn More 3D Laser Scan Learn More 3D Syringe | 3/5/10ml Learn More 3D Syringe | Cold Learn More 3D Syringe | UV Learn More Pipette Learn More 3D Dual Syringe | Coaxial Learn More 3D Syringe | 3/5/10ml (Mechanical) Learn More 3D Syringe | 30ml Learn More 3D Syringe | Hot Learn More 8-Channel Pipette Learn More 3D Dual Syringe | Mix Learn More 3D Syringe | 100ml Learn More 3D Syringe | 500ml Learn More 3D Syringe | Hot + UV Learn More Pick & Place Learn More Create a Hand for BAB. Have an idea for a tool? Our team can help design, manufacture, and test your idea! Ready to use a BioAssemblyBot Hands? Book a demo or get a quote: Email Alert Message Which BioAssemblyBot Hands are you interested in? 3D Syringe (3, 5, 10 mL) 3D Syringe (30 mL) 3D Syringe (100 mL) 3D Syringe (500 mL) 3D Syringe | Hot 3D Syringe | Cold 3D Syringe | UV 3D Syringe | Hot + UV 3D Dual Syringe 3D Dual Syringe | Mix 3D Dual Syringe | Coaxial 3D Laser Scan Pick & Place Pipette Build My Own Join the Community to receive periodic updates on advancements with Advanced Solutions Thanks! We'll be in touch soon! Submit > Quote The Advanced Solutions Louisville, KY facility has been audited by UL Registrar LLC and meets GMP requirements listed in RCP, NBCP, or Pharmaceutical Certification Schemes which is uniquely accredited by the American National Standard Institute (ANSI) developed in accordance with applicable sections of the FDA’s code of federal regulations.

Get Quote Pipette ​ Overview Advanced Solutions’ Pipette BioAssemblyTool™ brings ultra-precise liquid handling robotics into a single tool form factor. Using BioApps, BAB users easily define & execute media exchanges, deposit dye for 3D imaging, cell seeding, or even adding drug candidates for 3D assays. Utilizing BAB’s multi-axis robotic arm, users can pipette at pre-defined angles that were previously only possible with a human hand. Features Automate pipetting throughout your 3D bioprinting and biofabrication workflow Compatible with standard pipette tips including clear or black (conductive) with 10, 20, 25, 50, 175, 200, and 1,000 µL capacities Dispense speed of 1 µL/second up to 3000 µL/second Volume resolution of 0.024µL/step with 48000 increments/full stroke Automatic detection of liquid levels, tips, blockage, step loss, and more Integrated tip ejection Compatibility BioAssemblyBot 200, BioAssemblyBot 400, BioAssemblyBot 500 ASLS-0000222 Recommended 3D Laser Scan ​ Learn More Pick & Place ​ Learn More 3D Dual Syringe Pneumatic Dispense Learn More

Get Quote Pick & Place ​ Overview Advanced Solutions’ Pick & Place BioAssemblyTool™ is essential for automation of research and development or high speed through workflows. Gain high efficiency and accuracy with your science by eliminating time consuming material handling tasks. Unlike traditional 3D bioprinters that require manual intervention, additional robotic arms, or lab automation systems to move labware through a workflow, Pick & Place enables BAB users to rapidly increase throughput of the fabrication of their complex in-vitro models. Features Enables automated high-throughput 3D bioprinting and biofabrication Custom pick & place arms automate transport of well plates, petri dishes, or test tubes Directly interfaces BAB to other equipment such as well plate stackers, bioreactors, incubators, centrifuges, and tissue dissociation platforms Out-of-the-box integrations with BioStorageBot® and Cytiva’s InCell Analyzer confocal scanning microscope Compatibility BioAssemblyBot 200, BioAssemblyBot 400, BioAssemblyBot 500 ASLS-000138 Recommended Pipette ​ Learn More 3D Laser Scan ​ Learn More 3D Syringe | Cold Pneumatic Dispense Learn More

Get Quote 3D Syringe | Hot Pneumatic Dispense Overview Advanced Solutions’ 3D Syringe | Hot is a heat-controlled bioprinthead designed for printing thermoplastics, hydrogels, and pastes. Primary applications include the fabrication of hard tissue scaffolds, microfluidic devices, and medical devices. This printhead has a heating capacity of up to 150C, making it compatible with a variety of FDA compliant plastics such as PCL & PLGA. 3D Syringe | Hot tools can maintain their temperature on-bay, giving our users freedom to test prints without pre-maturely warming their bioinks as well as maintains sensitive materials at the required temperature throughout the printing process Features Pneumatic, multi-axis 3D bioprinthead enables melt extrusion Quick-release barrel holders enables easy & clean loading and cleaning of pellet materials Maintains temperature throughout workflow – including on-bay and during printing Ideal for printing thermoplastics such as PCL, PLA, and PLGA Compatible with 30-mL stainless steel or Nordson EFD high-temperature syringe barrels Automated tip detection & calibration Seamlessly 3D bioprints with TSIM® software, or include an in automated biofabrication workflow with BioApps™ Compatibility BioAssemblyBot 200, BioAssemblyBot 400, BioAssemblyBot 500 ASLS-0000104 (30 mL) Recommended 3D Syringe | Cold Pneumatic Dispense Learn More 3D Syringe | Hot + UV Pneumatic Dispense Learn More 3D Dual Syringe Pneumatic Dispense Learn More

Get Quote 3D Dual Syringe | Mix Pneumatic Dispense Overview Advanced Solutions’ 3D Syringe | Mix printhead gives users a unique ability to blend two materials for extrusion out of one syringe tip. Whether using multi-component materials for chemical or ionic crosslinking, or 3D printing defined gradients of cells and ECM, 3D Syringe | Mix unlocks gradient & mixing capabilities on TSIM® that drastically simplify multi-material 3D bioprinting. Features Pneumatic extrusion-based, multi-axis 3D bioprinthead enables users to print gradients utilizing two 3, 5, or 10 mL syringe barrels Quick-release clamps enable easy & clean loading of biomaterials Ideal for 3D printing multi-component bioinks Seamlessly control, gradient printing, and mixing ratios to 3D bioprint with TSIM® software, or include an in automated biofabrication workflow with BioApps™ Compatibility BioAssemblyBot 200, BioAssemblyBot 400, BioAssemblyBot 500 ASLS-0000106 (2 x 3, 5, 10 mL) Recommended 3D Dual Syringe Pneumatic Dispense Learn More Pipette ​ Learn More 3D Dual Syringe | Coaxial Pneumatic Dispense Learn More

Get Quote 3D Syringe | 500ml Pneumatic Dispense Overview Advanced Solutions’ 3D Syringe is an ambient extrusion printhead for use with BioAssemblyBot®. Simple, powerful, and rigorously tested for quality, this printhead is best used with bioinks that do not require thermal or cooled conditions. Example materials including hydrogels, pastes, cells and other ambient bioinks. Features Multi-axis 3D printhead maintains cell viability through the printing process Quick-release clamp enables easy & clean loading Ideal for non-temperature sensitive biomaterials Automated tip detection & calibration Seamlessly 3D bioprints with TSIM software, or include an in automated biofabrication workflow with BioApps Compatibility BioAssemblyBot 400, BioAssemblyBot 500 ASLS-0000255 (500 mL) Recommended 3D Syringe | 3/5/10ml Pneumatic Dispense Learn More 3D Dual Syringe | Coaxial Pneumatic Dispense Learn More 3D Syringe | Cold Pneumatic Dispense Learn More

Get Quote 3D Dual Syringe Pneumatic Dispense Overview Advanced Solutions’ 3D Syringe | Dual bioprinthead is the first of its kind – a dual-extrusion printhead that enables users to print at ambient temperatures with multiple bioinks in one run. Utilizing the six-axis freedom of BAB’s robotic arm, this tool was designed to help BAB Users rapidly switch between two bioinks during biofabrication. Features Pneumatic extrusion-based, multi-axis 3D bioprinthead enables rapid extrusion between two 10 ml syringe barrels Quick-release barrel holders enable easy & clean loading of biomaterials Ideal for printing biomaterials into separate tissue compartments as well as two component prints Seamlessly control material profile and 3D bioprint with TSIM® software, or include an in automated biofabrication workflow with BioApps™ Compatibility BioAssemblyBot 400, BioAssemblyBot 500 ASLS-0000196 (2 x 10mL) Recommended 3D Dual Syringe | Mix Pneumatic Dispense Learn More 3D Dual Syringe | Coaxial Pneumatic Dispense Learn More 3D Syringe | 30ml Pneumatic Dispense Learn More

Get Quote 3D Syringe | 3/5/10ml (Mechanical) Mechanical Dispense Overview Advanced Solutions’ 3D Syringe is an ambient mechanical printhead for use with BioAssemblyBot®. Simple, powerful, and rigorously tested for quality, this printhead is best used with bioinks that do not require thermal or cooled conditions. Example materials including hydrogels, pastes, cells and other ambient bioinks. Features Multi-axis 3D printhead maintains cell viability through the printing process Quick-release clamp enables easy & clean loading Ideal for non-temperature sensitive biomaterials Automated tip detection & calibration Seamlessly 3D bioprints with TSIM software, or include an in automated biofabrication workflow with BioApps Compatibility BioAssemblyBot 200, BioAssemblyBot 400, BioAssemblyBot 500 ASLS-0000227 Recommended 3D Syringe | 3/5/10ml Pneumatic Dispense Learn More 3D Syringe | 100ml Pneumatic Dispense Learn More 3D Syringe | 30ml Pneumatic Dispense Learn More

Get Quote 3D Laser Scan ​ Overview Advanced Solutions' 3D Laser Scan BioAssemblyTool™ is included with each BAB. With highly accurate point cloud resolution, the 3D Laser Scan BioAssemblyTool™ offers a way to seamlessly scan any 3D objection from the BioAssemblyBot® to TSIM® 3D Design software. Users love the ability to 3D scan anatomical models, microfluidic devices, and existing tissue constructs - and then easily incorporate 3D contour bioprint workflows on and around these objects with the high precision of BAB’s multi-axis robotic arm. Features <10 µm z-axis 3D laser scanning resolution Seamlessly 3D scan physical models and import this into TSIM® for manipulation and 3D design; bring laser quality scanning into biofabrication workflow with BioApps™ Ideal for scanning anatomical models, microfluidic devices Compatibility BioAssemblyBot 200, BioAssemblyBot 400, BioAssemblyBot 500 Recommended Pipette ​ Learn More Pick & Place ​ Learn More 3D Syringe | Hot + UV Pneumatic Dispense Learn More

Get Quote 3D Syringe | Hot + UV Pneumatic Dispense Overview Advanced Solutions’ 3D Syringe | Hot + UV enables users to easily 3D bioprint photocurable biomaterials such as methacrylated materials. Utilizing BioApps™ software, BAB users can easily & quickly define UV curing pathways into their biofabrication workflows to occur during extrusion or as a post-processing step. Our UV Disinfection tool can be used before a print to ensure sterility (along with our BAB Sterilization Protocol) of the build environment. 3D Syringe | Hot + UV includes a heating element, able to achieve temperatures of 40C to melt, print, and cure simultaneously. Features Pneumatic extrusion-based, multi-axis 3D bioprinthead enables bioprinting with materials that require light based crosslinking Quick-release barrel holder enables easy & clean loading of biomaterials Maintains temperature throughout workflow – including on-bay and during printing Ideal for 3D printing UV curable biomaterials including such as GelMA Heating capacity up to 40C UV wavelengths of 365nm or 405nm Compatible with 30-mL syringe barrels Seamlessly control temperature,3D bioprint, and crosslink the material with TSIM® software, or include an in automated biofabrication workflow with BioApps™ Compatibility BioAssemblyBot 400 ASLS-0000261 (30 mL) Recommended 3D Syringe | UV Pneumatic Dispense Learn More 3D Syringe | Hot Pneumatic Dispense Learn More Pipette ​ Learn More

Get Quote 3D Dual Syringe | Coaxial Pneumatic Dispense Overview Advanced Solutions’ 3D Dual Syringe | Coaxial printhead gives users a unique ability to blend two materials for extrusion out of one syringe tip. Whether using multi-component materials for chemical or ionic crosslinking, or 3D printing defined gradients of cells and ECM, 3D Dual Syringe | Coaxial unlocks gradient & mixing capabilities on TSIM® that drastically simplify multi-material 3D bioprinting. Taking the benefits of the 3D Dual Syringe but with increased functionality to include coaxial 3D bioprinting – the ability to simultaneously print a core and shell out of different biomaterials. Features Pneumatic extrusion-based, multi-axis 3D bioprinthead enables users to print gradients utilizing two 3, 5, or 10 mL syringe barrels in a coaxial manner Quick-release clamps enable easy & clean loading of biomaterials Ideal for 3D printing multi-component bioinks Seamlessly control, gradient printing, and mixing ratios to 3D bioprint with TSIM® software, or include an in automated biofabrication workflow with BioApps™ Compatibility BioAssemblyBot 200, BioAssemblyBot 400, BioAssemblyBot 500 ASLS-0000213 (2 x 3,5, 10 mL) Recommended 3D Dual Syringe | Mix Pneumatic Dispense Learn More Pick & Place ​ Learn More 3D Syringe | Hot + UV Pneumatic Dispense Learn More

Get Quote 3D Syringe | 3/5/10ml Pneumatic Dispense Overview Advanced Solutions’ 3D Syringe is an ambient extrusion printhead for use with BioAssemblyBot®. Simple, powerful, and rigorously tested for quality, this printhead is best used with bioinks that do not require thermal or cooled conditions. Example materials including hydrogels, pastes, cells and other ambient bioinks. Features Multi-axis 3D printhead maintains cell viability through the printing process Quick-release clamp enables easy & clean loading Ideal for non-temperature sensitive biomaterials Automated tip detection & calibration Seamlessly 3D bioprints with TSIM software, or include an in automated biofabrication workflow with BioApps Compatibility BioAssemblyBot 200, BioAssemblyBot 400, BioAssemblyBot 500 ASLS-0000101 (3 mL) ASLS-0000103 (5 mL) ASLS-0000102 (10 mL) Recommended 3D Syringe | 30ml Pneumatic Dispense Learn More 3D Dual Syringe Pneumatic Dispense Learn More 3D Syringe | 100ml Pneumatic Dispense Learn More

Get Quote 3D Syringe | Cold Pneumatic Dispense Overview Advanced Solutions’ 3D Syringe | Cold printhead was designed to cool biomaterials to their printable temperatures. Available in 3, 5, 10- or 30-mL form factors, use 3D Syringe | Cold to build & fill microfluidic devices and a wide variety of 3D bioprinted constructs. Our cold tools are able to maintain their temperature on-bay, giving our users freedom to test prints without pre-maturely warming their bioinks as well as maintains sensitive materials at the required temperature throughout the printing process. Features Pneumatic extrusion-based, multi-axis 3D bioprinthead enables cold-temperature based bioprinting Quick-release barrel holder enables easy & clean loading of biomaterials Maintains temperature throughout workflow – including on-bay and during printing Ideal for 3D printing chilled biomaterials including such as collagen, gelatin Cooling capacity down to 0 C Compatible with 3, 5, 10 and 30-mL syringe barrels Seamlessly control temperature and 3D bioprint with TSIM® software, or include an automated biofabrication workflow with BioApps™ Compatibility BioAssemblyBot 200, BioAssemblyBot 400, BioAssemblyBot 500 ASLS-0000197 (3,5, 10 mL) ASLS-0000105 (30 mL) Recommended 3D Syringe | Hot Pneumatic Dispense Learn More 3D Dual Syringe Pneumatic Dispense Learn More 3D Syringe | Cold Pneumatic Dispense Learn More

Get Quote 8-Channel Pipette Pneumatic Dispense Overview Advanced Solutions’ 8 Channel Pipette BioAssemblyBot Hand® brings ultra-precise, rapid liquid handling robotics into a single tool form factor. Using BioApps, BAB users easily define & execute media exchanges, deposit dye for 3D imaging, cell seeding, or even adding drug candidates for 3D assays. Utilizing BAB’s multi-axis robotic arm, users can pipette at pre-defined angles that were previously only possible with a human hand. Features Automate pipetting throughout your 3D bioprinting and biofabrication workflow Compatible with standard pipette tips including clear or black (conductive) Automatic detection of liquid levels, tips, blockage, step loss, and more Integrated tip ejection Compatibility BioAssemblyBot 400, BioAssemblyBot 500 Recommended Pipette ​ Learn More Pick & Place ​ Learn More 3D Dual Syringe Pneumatic Dispense Learn More

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Organoids/Spheroids Get Started One platform, better outcomes. Use one platform to build and handle all organoid/spheroid types and sizes without damage. BioAssemblyBot (#WeCallHerBAB) empowers the freedom to design and automate organoid/spheroid models and assays. Unleash the investigative power of organoids/spheroids. Spend more time on the science by automating basic, pharmacological, and biomedical research experimental workflows. Cost effectively answer questions related to cell-to-cell interactions, developmental processes, responses to external stimuli, and disease mechanisms. Realize higher throughput with BAB's robotic workflow capability. BAB automatically dispenses a prescribed quantity of cells and media into a variety of standard and custom well plates to form organoids/spheroids. Over defined intervals, BAB will exchange growth and differentiation media without damaging the organoid/spheroid. Smart integrated workflows. BAB works well with others. Seamlessly integrate BAB with other lab equipment to image, incubate, measure, etc. organoid/spheroid development, and assay endpoints. Design and perform organoid/spheroids experimental models and assays. BAB enables a range of organoid/spheroid experimental strategies including free floating, suspension in domes of matrix, fluidic devices, etc. Spatially organize organoids and/or cells within an assay environment. Build microphysiological systems using organoids/spheroids. BAB combines standard and custom fluidic devices with organoids/spheroids to build and use organs-on-chips. Enhance your organoid/spheroid models through vascularization. Build blood vessels in your organoid/spheroid models using Angiomics microvessels and protocols. Learn More Get Quote Learn More Get Quote Learn More Get Quote Learn More Applications Show All Hide All Academic (College) ​ Research & Development Pharma ​ _ ​ Academic (College) ​ Research & Development ​ Pharma ​ _ Academic (College) ​ Research & Development ​ Pharma ​ Clinical Features Build simple to moderately complex organoid/spheroid models ​ 3D Additive Models ​ ​ Great Investigate organoid/spheroid models ​ Good Throughput & Workflow Capability ​ Great Build microphysiological systems using organoids/spheroids ​ 3D Print in Well Plates ​ 4-axis Robot ​ Biosafety Cabinet Compatible (without enclosure) ​ HEPA Filtration Optional ​ Build simple to highly complex organoid/spheroid models ​ 3D Additive & Contour Models ​ Great Investigate organoid/spheroid models ​ Great Throughput & Workflow Capability ​ Great Build microphysiological systems using organoids/spheroids ​ 3D Print in Well Plates ​ 6-axis Robot ​ _ ​ ​ HEPA Filtration Optional Build simple to highly complex organoid/spheroid models ​ 3D Additive & Contour Models ​ Great Investigate organoid/spheroid models ​ Great Throughput & Workflow Capability ​ Great Build microphysiological systems using organoids/spheroids ​ 3D Print in Well Plates ​ 6-axis Robot ​ Integrated Class II, Type A Biosafety Cabinet ​ Integrated HEPA Filtration Certifications TSIM Certified ​ BioApps Certified ​ UL cGMP Certified ​ UL/CE Certification in progress TSIM Certified ​ BioApps Certified ​ UL cGMP Certified ​ UL/CE Certified TSIM Certified ​ BioApps Certified ​ UL cGMP Certified ​ UL/CE Certification in progress Integrations Up to 5 BioAssemblyBot Hands in a single run ​ Good Agile integration with other lab equipment Up to 8 BioAssemblyBot Hands in a single run ​ Great Agile integration with other lab equipment Up to 10 BioAssemblyBot Hands in a single run ​ Great* Agile integration with other lab equipment *Requires BioBot Link Get Quote Learn More Get Quote Learn More Get Quote Learn More What organoid/spheroid researchers use with BAB: Buy Now Learn More Get Started Learn More Get Quote Learn More Get Quote Learn More View All Products Explore more solutions: 3D Bioprinting Bioprint in ways you never thought possible. See This Solution Advanced 3D Tissue Models Mimic human tissues by capturing more of the native biology. See This Solution Vascularization Bring your tissue to life. See This Solution Ready to get started? Connect with an Organoid/Spheroid expert: Email Alert Message Join the Community to receive periodic updates on advancements with Advanced Solutions Thanks! We'll be in touch soon! Submit > OS Quote The BioAssemblyBot 400 is certified by UL in accordance with applicable safety requirements. The BioAssemblyBot 400 is certified by UL in accordance with applicable energy efficiency requirements. ​ The Advanced Solutions Louisville, KY facility has been audited by UL Registrar LLC and meets GMP requirements listed in RCP, NBCP, or Pharmaceutical Certification Schemes which is uniquely accredited by the American National Standard Institute (ANSI) developed in accordance with applicable sections of the FDA’s code of federal regulations.

Consulting Services Overview Applications Get Started Consulting Services 30 years of 3D assay experience - plus automated biomanufacturing laboratories, at your call. Overview Design & execute complex science from anywhere. With a UL cGMP certified facility in Louisville, KY and a state-of-art research laboratory in Manchester, NH, the Advanced Solutions team of scientists and engineers and further your science. Our specialists have access to a tissue culture wet lab featuring the latest robotic scientific equipment including BioAssemblyBots , BioStorageBots , biosafety cabinets, confocal microscopes, and more. Our team is knowledgeable in our cutting-edge software like TSIM, BioSegment, BioApps, BioApps Maker, and third-party software like the Microsoft suite of software. We will work with you to craft custom solutions including vasculature and tissue models and provide guidance to further your science. Our tissue design process: Design Design Collaboratively design 3D tissue models and assays Make Make Our team develops 3D tissue protocols to exact specifications and throughput Validate Validate Our team tests and qualifies 3D assay results Innovate Innovate Our team transfers all protocols and know-how back to your team to research and innovate Solutions Vascularized Liver. Thick, 3D vascularized hepatic tissue model. Lymph Node Model. Understanding immune cell dynamics. Ultrasound Cell Patterning. Positioning cells in different experimental configurations. Angiogenesis Guidance. Direct vascular self-assembly with stromal cells. Contact | Consulting Services Let's start your discoveries. Connect with our team to arrange an introductory call. Email Alert Message Join the Community to receive periodic updates on advancements with Advanced Solutions Thanks! We'll be in touch soon! Submit > Angiomics Human Adipose Microvessels by Advanced Solutions are for RESEARCH USE ONLY and not for use in humans under any circumstances. Advanced Solutions Life Sciences, LLC. and Advanced Solutions, Inc. are not responsible or liable for how this product is used. The RESEARCH USE ONLY limitation supersedes any written, oral, or implied understanding between the parties. View Human Adispose Microvessels Safety Data The Advanced Solutions Louisville, KY facility has been audited by UL Registrar LLC and meets GMP requirements listed in RCP, NBCP, or Pharmaceutical Certification Schemes which is uniquely accredited by the American National Standard Institute (ANSI) developed in accordance with applicable sections of the FDA’s code of federal regulations.

Get Quote Vascularized Adipose Organoids Manufacturing Advanced Solutions BioAssembly Automation Talk with an Expert Schedule a Demo Read the full publication here. VAOs contain mature adipocytes and native microvasculatures in a high cell-density organoid, making them ideal for informative experiments and assays. Example customer outcomes include examining: Adipose metabolism Inflammation Insulin sensitivity This BioApp allows you to: Build a single 96 well plate of VAOs in 5 minutes using BioAssemblyBot 400 Incubate 36 or more well plates per day using BioStorageBot Hive This BioApp automates the manufacturing of VAOs: The BioAssemblyBot uses the Pick & Place BioAssemblyTool to place a well plate onto the stage. Then it uses the Pipette BioAssemblyTool to easily pipette an exact amount of Angiomics Microvessels into the well plate. Finally, it uses the Pick & Place BioAssemblyTool to move the well plate into the BioStorageBot Hive for incubation. This BioApp is completed with: Pick & Place, Pipette Microvessels 96-cell well plate(s) Recommended BioApps for you: Create Your Own BioApp Learn More GetStarted Get started with this BioApp: Email Alert Message Join the Community to receive periodic updates on advancements with Advanced Solutions Submit Thanks! A member of our team will be in touch soon!